Dr. Serge Gauthier


  1. Gauthier, S, Aisen, PS, Cummings, J, Detke, MJ, Longo, FM, Raman, R et al.. Non-Amyloid Approaches to Disease Modification for Alzheimer's Disease: An EU/US CTAD Task Force Report. J Prev Alzheimers Dis. 2020; :1-6. doi: 10.14283/jpad.2020.18. PubMed PMID:32420298 PubMed Central PMC7223540.
  2. Karikari, TK, Pascoal, TA, Ashton, NJ, Janelidze, S, Benedet, AL, Rodriguez, JL et al.. Blood phosphorylated tau 181 as a biomarker for Alzheimer's disease: a diagnostic performance and prediction modelling study using data from four prospective cohorts. Lancet Neurol. 2020;19 (5):422-433. doi: 10.1016/S1474-4422(20)30071-5. PubMed PMID:32333900 .
  3. Shiells, H, Schelter, BO, Bentham, P, Baddeley, TC, Rubino, CM, Ganesan, H et al.. Concentration-Dependent Activity of Hydromethylthionine on Clinical Decline and Brain Atrophy in a Randomized Controlled Trial in Behavioral Variant Frontotemporal Dementia. J. Alzheimers Dis. 2020;75 (2):501-519. doi: 10.3233/JAD-191173. PubMed PMID:32280089 .
  4. Wang, H, Li, T, Gauthier, S, Yu, E, Tang, Y, Barbarino, P et al.. Coronavirus epidemic and geriatric mental healthcare in China: how a coordinated response by professional organizations helped older adults during an unprecedented crisis. Int Psychogeriatr. 2020; :1-4. doi: 10.1017/S1041610220000551. PubMed PMID:32268928 PubMed Central PMC7184143.
  5. Wang, H, Li, T, Barbarino, P, Gauthier, S, Brodaty, H, Molinuevo, JL et al.. Dementia care during COVID-19. Lancet. 2020;395 (10231):1190-1191. doi: 10.1016/S0140-6736(20)30755-8. PubMed PMID:32240625 PubMed Central PMC7146671.
  6. Therriault, J, Benedet, AL, Pascoal, TA, Mathotaarachchi, S, Savard, M, Chamoun, M et al.. APOEε4 potentiates the relationship between amyloid-β and tau pathologies. Mol. Psychiatry. 2020; :. doi: 10.1038/s41380-020-0688-6. PubMed PMID:32161362 .
  7. Lussier, FZ, Pascoal, TA, Chamoun, M, Therriault, J, Tissot, C, Savard, M et al.. Mild behavioral impairment is associated with β-amyloid but not tau or neurodegeneration in cognitively intact elderly individuals. Alzheimers Dement. 2020;16 (1):192-199. doi: 10.1002/alz.12007. PubMed PMID:31914223 PubMed Central PMC7041633.
  8. Wang, H, Xie, H, Qu, Q, Chen, W, Sun, Y, Zhang, N et al.. The continuum of care for dementia: needs, resources and practice in China. J Glob Health. 2019;9 (2):020321. doi: 10.7189/jogh.09.020321. PubMed PMID:31893030 PubMed Central PMC6925963.
  9. Wang, H, Fan, Z, Shi, C, Xiong, L, Zhang, H, Li, T et al.. Consensus statement on the neurocognitive outcomes for early detection of mild cognitive impairment and Alzheimer dementia from the Chinese Neuropsychological Normative (CN-NORM) Project. J Glob Health. 2019;9 (2):020320. doi: 10.7189/jogh.09.020320. PubMed PMID:31893029 PubMed Central PMC6925962.
  10. Therriault, J, Benedet, AL, Pascoal, TA, Mathotaarachchi, S, Chamoun, M, Savard, M et al.. Association of Apolipoprotein E ε4 With Medial Temporal Tau Independent of Amyloid-β. JAMA Neurol. 2020;77 (4):470-479. doi: 10.1001/jamaneurol.2019.4421. PubMed PMID:31860000 PubMed Central PMC6990684.
  11. Ng, KP, Chiew, HJ, Rosa-Neto, P, Kandiah, N, Ismail, Z, Gauthier, S et al.. Brain Metabolic Dysfunction in Early Neuropsychiatric Symptoms of Dementia. Front Pharmacol. 2019;10 :1398. doi: 10.3389/fphar.2019.01398. PubMed PMID:31824321 PubMed Central PMC6882863.
  12. Ng, KP, Therriault, J, Kang, MS, Struyfs, H, Pascoal, TA, Mathotaarachchi, S et al.. Rasagiline, a monoamine oxidase B inhibitor, reduces in vivo [18F]THK5351 uptake in progressive supranuclear palsy. Neuroimage Clin. 2019;24 :102091. doi: 10.1016/j.nicl.2019.102091. PubMed PMID:31795034 PubMed Central PMC6889764.
  13. Belleville, S, LeBlanc, AC, Kergoat, MJ, Calon, F, Gaudreau, P, Hébert, SS et al.. The Consortium for the early identification of Alzheimer's disease-Quebec (CIMA-Q). Alzheimers Dement (Amst). 2019;11 :787-796. doi: 10.1016/j.dadm.2019.07.003. PubMed PMID:31788534 PubMed Central PMC6880140.
  14. Benedet, AL, Ashton, NJ, Pascoal, TA, Leuzy, A, Mathotaarachchi, S, Kang, MS et al.. Plasma neurofilament light associates with Alzheimer's disease metabolic decline in amyloid-positive individuals. Alzheimers Dement (Amst). 2019;11 :679-689. doi: 10.1016/j.dadm.2019.08.002. PubMed PMID:31673598 PubMed Central PMC6816316.
  15. Schelter, BO, Shiells, H, Baddeley, TC, Rubino, CM, Ganesan, H, Hammel, J et al.. Concentration-Dependent Activity of Hydromethylthionine on Cognitive Decline and Brain Atrophy in Mild to Moderate Alzheimer's Disease. J. Alzheimers Dis. 2019;72 (3):931-946. doi: 10.3233/JAD-190772. PubMed PMID:31658058 PubMed Central PMC6918900.
  16. Sharafi, SM, Sylvestre, JP, Chevrefils, C, Soucy, JP, Beaulieu, S, Pascoal, TA et al.. Vascular retinal biomarkers improves the detection of the likely cerebral amyloid status from hyperspectral retinal images. Alzheimers Dement (N Y). 2019;5 :610-617. doi: 10.1016/j.trci.2019.09.006. PubMed PMID:31650017 PubMed Central PMC6804547.
  17. Ng, KP, Richard-Devantoy, S, Bertrand, JA, Jiang, L, Pascoal, TA, Mathotaarachchi, S et al.. Suicidal ideation is common in autosomal dominant Alzheimer's disease at-risk persons. Int J Geriatr Psychiatry. 2020;35 (1):60-68. doi: 10.1002/gps.5215. PubMed PMID:31642105 PubMed Central PMC7232741.
  18. Hadoux, X, Hui, F, Lim, JKH, Masters, CL, Pébay, A, Chevalier, S et al.. Non-invasive in vivo hyperspectral imaging of the retina for potential biomarker use in Alzheimer's disease. Nat Commun. 2019;10 (1):4227. doi: 10.1038/s41467-019-12242-1. PubMed PMID:31530809 PubMed Central PMC6748929.
  19. Jia, L, Quan, M, Fu, Y, Zhao, T, Li, Y, Wei, C et al.. Dementia in China: epidemiology, clinical management, and research advances. Lancet Neurol. 2020;19 (1):81-92. doi: 10.1016/S1474-4422(19)30290-X. PubMed PMID:31494009 .
  20. Chertkow, H, Borrie, M, Whitehead, V, Black, SE, Feldman, HH, Gauthier, S et al.. The Comprehensive Assessment of Neurodegeneration and Dementia: Canadian Cohort Study. Can J Neurol Sci. 2019;46 (5):499-511. doi: 10.1017/cjn.2019.27. PubMed PMID:31309917 .
  21. Cui, Y, Dai, S, Miao, Z, Zhong, Y, Liu, Y, Liu, L et al.. Reliability and Validity of the Chinese Version of the Mild Behavioral Impairment Checklist for Screening for Alzheimer's Disease. J. Alzheimers Dis. 2019;70 (3):747-756. doi: 10.3233/JAD-190113. PubMed PMID:31256131 .
  22. Pascoal, TA, Mathotaarachchi, S, Kang, MS, Mohaddes, S, Shin, M, Park, AY et al.. Aβ-induced vulnerability propagates via the brain's default mode network. Nat Commun. 2019;10 (1):2353. doi: 10.1038/s41467-019-10217-w. PubMed PMID:31164641 PubMed Central PMC6547716.
  23. Gauthier, S, Gagnon, L, Rochon, A. Users' perspectives on medical assistance in dying for persons with dementia. Int J Geriatr Psychiatry. 2019;34 (7):905. doi: 10.1002/gps.5115. PubMed PMID:30958580 .
  24. Gagnon, K, Baril, AA, Montplaisir, J, Carrier, J, De Beaumont, L, D'Aragon, C et al.. Disconnection Between Self-Reported and Objective Cognitive Impairment in Obstructive Sleep Apnea. J Clin Sleep Med. 2019;15 (3):409-415. doi: 10.5664/jcsm.7664. PubMed PMID:30853044 PubMed Central PMC6411171.
  25. Su, Y, Flores, S, Wang, G, Hornbeck, RC, Speidel, B, Joseph-Mathurin, N et al.. Comparison of Pittsburgh compound B and florbetapir in cross-sectional and longitudinal studies. Alzheimers Dement (Amst). 2019;11 :180-190. doi: 10.1016/j.dadm.2018.12.008. PubMed PMID:30847382 PubMed Central PMC6389727.
  26. Liu, J, Wang, Q, Jing, D, Gao, R, Zhang, J, Cui, C et al.. Diagnostic Approach of Early-Onset Dementia with Negative Family History: Implications from Two Cases of Early-Onset Alzheimer's Disease with De Novo PSEN1 Mutation. J. Alzheimers Dis. 2019;68 (2):551-558. doi: 10.3233/JAD-181108. PubMed PMID:30814350 .
  27. Gordon, BA, Blazey, TM, Christensen, J, Dincer, A, Flores, S, Keefe, S et al.. Tau PET in autosomal dominant Alzheimer's disease: relationship with cognition, dementia and other biomarkers. Brain. 2019;142 (4):1063-1076. doi: 10.1093/brain/awz019. PubMed PMID:30753379 PubMed Central PMC6439328.
  28. Reisberg, B, Torossian, C, Shulman, MB, Monteiro, I, Boksay, I, Golomb, J et al.. Two Year Outcomes, Cognitive and Behavioral Markers of Decline in Healthy, Cognitively Normal Older Persons with Global Deterioration Scale Stage 2 (Subjective Cognitive Decline with Impairment). J. Alzheimers Dis. 2019;67 (2):685-705. doi: 10.3233/JAD-180341. PubMed PMID:30689585 .
  29. Thorogood, A, Mäki-Petäjä-Leinonen, A, Dalpé, G, Gastmans, C, Gauthier, S. Openness, inclusion, and respect in dementia research. Lancet Neurol. 2019;18 (2):135-136. doi: 10.1016/S1474-4422(18)30445-9. PubMed PMID:30663603 .
  30. Schilling, LP, Pascoal, TA, Zimmer, ER, Mathotaarachchi, S, Shin, M, de Mello Rieder, CR et al.. Regional Amyloid-β Load and White Matter Abnormalities Contribute to Hypometabolism in Alzheimer's Dementia. Mol. Neurobiol. 2019;56 (7):4916-4924. doi: 10.1007/s12035-018-1405-1. PubMed PMID:30414086 .
  31. Zhang, H, Ng, KP, Therriault, J, Kang, MS, Pascoal, TA, Rosa-Neto, P et al.. Cerebrospinal fluid phosphorylated tau, visinin-like protein-1, and chitinase-3-like protein 1 in mild cognitive impairment and Alzheimer's disease. Transl Neurodegener. 2018;7 :23. doi: 10.1186/s40035-018-0127-7. PubMed PMID:30311914 PubMed Central PMC6161434.
  32. Thorogood, A, Mäki-Petäjä-Leinonen, A, Brodaty, H, Dalpé, G, Gastmans, C, Gauthier, S et al.. Consent recommendations for research and international data sharing involving persons with dementia. Alzheimers Dement. 2018;14 (10):1334-1343. doi: 10.1016/j.jalz.2018.05.011. PubMed PMID:30293575 .
  33. Ng, KP, Chiew, HJ, Lim, L, Rosa-Neto, P, Kandiah, N, Gauthier, S et al.. The influence of language and culture on cognitive assessment tools in the diagnosis of early cognitive impairment and dementia. Expert Rev Neurother. 2018;18 (11):859-869. doi: 10.1080/14737175.2018.1532792. PubMed PMID:30286681 .
  34. Gagnon, K, Baril, AA, Montplaisir, J, Carrier, J, Chami, S, Gauthier, S et al.. Detection of mild cognitive impairment in middle-aged and older adults with obstructive sleep apnoea. Eur. Respir. J. 2018;52 (5):. doi: 10.1183/13993003.01137-2018. PubMed PMID:30190270 .
  35. Zhang, H, Therriault, J, Kang, MS, Ng, KP, Pascoal, TA, Rosa-Neto, P et al.. Cerebrospinal fluid synaptosomal-associated protein 25 is a key player in synaptic degeneration in mild cognitive impairment and Alzheimer's disease. Alzheimers Res Ther. 2018;10 (1):80. doi: 10.1186/s13195-018-0407-6. PubMed PMID:30115118 PubMed Central PMC6097333.
  36. Gauthier, S, Herrmann, N, Rosa-Neto, P. Optimal use of cholinergic drugs in Alzheimer's disease. Brain. 2018;141 (9):e68. doi: 10.1093/brain/awy204. PubMed PMID:30084978 .
  37. Pascoal, TA, Shin, M, Kang, MS, Chamoun, M, Chartrand, D, Mathotaarachchi, S et al.. In vivo quantification of neurofibrillary tangles with [18F]MK-6240. Alzheimers Res Ther. 2018;10 (1):74. doi: 10.1186/s13195-018-0402-y. PubMed PMID:30064520 PubMed Central PMC6069775.
  38. Jia, J, Wei, C, Chen, S, Li, F, Tang, Y, Qin, W et al.. Efficacy and safety of the compound Chinese medicine SaiLuoTong in vascular dementia: A randomized clinical trial. Alzheimers Dement (N Y). 2018;4 :108-117. doi: 10.1016/j.trci.2018.02.004. PubMed PMID:29955654 PubMed Central PMC6021260.
  39. Wu, LY, Zhan, SQ, Huang, ZY, Zhang, B, Wang, T, Liu, CF et al.. Expert Consensus on Clinical Diagnostic Criteria for Fatal Familial Insomnia. Chin. Med. J. 2018;131 (13):1613-1617. doi: 10.4103/0366-6999.235115. PubMed PMID:29941716 PubMed Central PMC6032681.
  40. Khachaturian, AS, Hayden, KM, Mielke, MM, Tang, Y, Lutz, MW, Gold, M et al.. New thinking about thinking, part two. Theoretical articles for Alzheimer's & Dementia. Alzheimers Dement. 2018;14 (6):703-706. doi: 10.1016/j.jalz.2018.05.002. PubMed PMID:29842864 .
  41. Gauthier, S, Ng, KP, Pascoal, TA, Zhang, H, Rosa-Neto, P. Targeting Alzheimer's Disease at the Right Time and the Right Place: Validation of a Personalized Approach to Diagnosis and Treatment. J. Alzheimers Dis. 2018;64 (s1):S23-S31. doi: 10.3233/JAD-179924. PubMed PMID:29504543 PubMed Central PMC6004905.
  42. Villeneuve, S, Vogel, JW, Gonneaud, J, Pichet Binette, A, Rosa-Neto, P, Gauthier, S et al.. Proximity to Parental Symptom Onset and Amyloid-β Burden in Sporadic Alzheimer Disease. JAMA Neurol. 2018;75 (5):608-619. doi: 10.1001/jamaneurol.2017.5135. PubMed PMID:29482212 PubMed Central PMC5885216.
  43. Schoemaker, D, Buss, C, Head, K, Sandman, CA, Davis, EP, Chakravarty, MM et al.. Corrigendum to "Hippocampus and amygdala volumes from magnetic resonance images in children: Assessing accuracy of FreeSurfer and FSL against manual segmentation"[NeuroImage 129 (2016) 1-14]. Neuroimage. 2018;173 :1-2. doi: 10.1016/j.neuroimage.2018.02.009. PubMed PMID:29477029 .
  44. Benedet, AL, Yu, L, Labbe, A, Mathotaarachchi, S, Pascoal, TA, Shin, M et al.. CYP2C19 variant mitigates Alzheimer disease pathophysiology in vivo and postmortem. Neurol Genet. 2018;4 (1):e216. doi: 10.1212/NXG.0000000000000216. PubMed PMID:29473050 PubMed Central PMC5820598.
  45. Mortby, ME, Black, SE, Gauthier, S, Miller, D, Porsteinsson, A, Smith, EE et al.. Dementia clinical trial implications of mild behavioral impairment. Int Psychogeriatr. 2018;30 (2):171-175. doi: 10.1017/S1041610218000042. PubMed PMID:29448970 .
  46. Therriault, J, Ng, KP, Pascoal, TA, Mathotaarachchi, S, Kang, MS, Struyfs, H et al.. Anosognosia predicts default mode network hypometabolism and clinical progression to dementia. Neurology. 2018;90 (11):e932-e939. doi: 10.1212/WNL.0000000000005120. PubMed PMID:29444971 PubMed Central PMC5858945.
  47. Jia, J, Wei, C, Chen, S, Li, F, Tang, Y, Qin, W et al.. The cost of Alzheimer's disease in China and re-estimation of costs worldwide. Alzheimers Dement. 2018;14 (4):483-491. doi: 10.1016/j.jalz.2017.12.006. PubMed PMID:29433981 .
  48. Pascoal, TA, Mathotaarachchi, S, Shin, M, Park, AY, Mohades, S, Benedet, AL et al.. Amyloid and tau signatures of brain metabolic decline in preclinical Alzheimer's disease. Eur. J. Nucl. Med. Mol. Imaging. 2018;45 (6):1021-1030. doi: 10.1007/s00259-018-3933-3. PubMed PMID:29396637 PubMed Central PMC5915512.
  49. Belleville, S, Hudon, C, Bier, N, Brodeur, C, Gilbert, B, Grenier, S et al.. MEMO+: Efficacy, Durability and Effect of Cognitive Training and Psychosocial Intervention in Individuals with Mild Cognitive Impairment. J Am Geriatr Soc. 2018;66 (4):655-663. doi: 10.1111/jgs.15192. PubMed PMID:29313875 .
  50. Sinyavskaya, L, Gauthier, S, Renoux, C, Dell'Aniello, S, Suissa, S, Brassard, P et al.. Comparative effect of statins on the risk of incident Alzheimer disease. Neurology. 2018;90 (3):e179-e187. doi: 10.1212/WNL.0000000000004818. PubMed PMID:29247073 .
  51. Li, X, Ba, M, Ng, KP, Mathotaarachchi, S, Pascoal, TA, Rosa-Neto, P et al.. Characterizing biomarker features of cognitively normal individuals with ventriculomegaly. Alzheimers Dement (Amst). 2018;10 :12-21. doi: 10.1016/j.dadm.2017.08.001. PubMed PMID:29159265 PubMed Central PMC5678356.
  52. Wilcock, GK, Gauthier, S, Frisoni, GB, Jia, J, Hardlund, JH, Moebius, HJ et al.. Potential of Low Dose Leuco-Methylthioninium Bis(Hydromethanesulphonate) (LMTM) Monotherapy for Treatment of Mild Alzheimer's Disease: Cohort Analysis as Modified Primary Outcome in a Phase III Clinical Trial. J. Alzheimers Dis. 2018;61 (1):435-457. doi: 10.3233/JAD-170560. PubMed PMID:29154277 PubMed Central PMC5734125.
  53. Gauthier, S, Robillard, J, de Champlain, J. Progress in transnational scientific and ethics review: Commentary on the proposal for a single North American review board for research on dementia. Alzheimers Dement. 2018;14 (1):115-116. doi: 10.1016/j.jalz.2017.10.001. PubMed PMID:29111430 .
  54. Parent, MJ, Zimmer, ER, Shin, M, Kang, MS, Fonov, VS, Mathieu, A et al.. Multimodal Imaging in Rat Model Recapitulates Alzheimer's Disease Biomarkers Abnormalities. J. Neurosci. 2017;37 (50):12263-12271. doi: 10.1523/JNEUROSCI.1346-17.2017. PubMed PMID:29097597 PubMed Central PMC5729194.
  55. Gauthier, S, Ng, KP, Pascoal, TA, Mathotaarachchi, S, Chung, CO, Benedetti, AL et al.. Author response: Neuropsychiatric symptoms predict hypometabolism in preclinical Alzheimer disease. Neurology. 2017;89 (18):1931. doi: 10.1212/WNL.0000000000004593. PubMed PMID:29084927 .
  56. Ba, M, Li, X, Ng, KP, Pascoal, TA, Mathotaarachchi, S, Rosa-Neto, P et al.. The prevalence and biomarkers' characteristic of rapidly progressive Alzheimer's disease from the Alzheimer's Disease Neuroimaging Initiative database. Alzheimers Dement (N Y). 2017;3 (1):107-113. doi: 10.1016/j.trci.2016.12.005. PubMed PMID:29067322 PubMed Central PMC5651370.
  57. Savaskan, E, Mueller, H, Hoerr, R, von Gunten, A, Gauthier, S. Treatment effects of Ginkgo biloba extract EGb 761® on the spectrum of behavioral and psychological symptoms of dementia: meta-analysis of randomized controlled trials. Int Psychogeriatr. 2018;30 (3):285-293. doi: 10.1017/S1041610217001892. PubMed PMID:28931444 .
  58. Schoemaker, D, Poirier, J, Collins, DL, Gauthier, S, Pruessner, JC. Familiarity deficits in cognitively normal aging individuals with APOE ε4: A follow-up investigation of medial temporal lobe structural correlates. Alzheimers Dement (Amst). 2017;9 :21-24. doi: 10.1016/j.dadm.2017.05.008. PubMed PMID:28761928 PubMed Central PMC5520953.
  59. Mathotaarachchi, S, Pascoal, TA, Shin, M, Benedet, AL, Kang, MS, Beaudry, T et al.. Identifying incipient dementia individuals using machine learning and amyloid imaging. Neurobiol. Aging. 2017;59 :80-90. doi: 10.1016/j.neurobiolaging.2017.06.027. PubMed PMID:28756942 .
  60. Lajoie, I, Nugent, S, Debacker, C, Dyson, K, Tancredi, FB, Badhwar, A et al.. Application of calibrated fMRI in Alzheimer's disease. Neuroimage Clin. 2017;15 :348-358. doi: 10.1016/j.nicl.2017.05.009. PubMed PMID:28560160 PubMed Central PMC5443910.
  61. Brayet, P, Petit, D, Baril, AA, Gosselin, N, Gagnon, JF, Soucy, JP et al.. Brain perfusion during rapid-eye-movement sleep successfully identifies amnestic mild cognitive impairment. Sleep Med. 2017;34 :134-140. doi: 10.1016/j.sleep.2017.01.025. PubMed PMID:28522082 .
  62. Müller, WE, Eckert, A, Eckert, GP, Fink, H, Friedland, K, Gauthier, S et al.. Therapeutic efficacy of the Ginkgo special extract EGb761® within the framework of the mitochondrial cascade hypothesis of Alzheimer's disease. World J. Biol. Psychiatry. 2019;20 (3):173-189. doi: 10.1080/15622975.2017.1308552. PubMed PMID:28460580 .
  63. Ng, KP, Pascoal, TA, Mathotaarachchi, S, Chung, CO, Benedet, AL, Shin, M et al.. Neuropsychiatric symptoms predict hypometabolism in preclinical Alzheimer disease. Neurology. 2017;88 (19):1814-1821. doi: 10.1212/WNL.0000000000003916. PubMed PMID:28404803 PubMed Central PMC5419982.
  64. Ng, KP, Pascoal, TA, Mathotaarachchi, S, Therriault, J, Kang, MS, Shin, M et al.. Monoamine oxidase B inhibitor, selegiline, reduces 18F-THK5351 uptake in the human brain. Alzheimers Res Ther. 2017;9 (1):25. doi: 10.1186/s13195-017-0253-y. PubMed PMID:28359327 PubMed Central PMC5374697.
  65. Schoemaker, D, Mascret, C, Collins, DL, Yu, E, Gauthier, S, Pruessner, JC et al.. Recollection and familiarity in aging individuals: Gaining insight into relationships with medial temporal lobe structural integrity. Hippocampus. 2017;27 (6):692-701. doi: 10.1002/hipo.22725. PubMed PMID:28281326 .
  66. Jia, J, Gauthier, S, Pallotta, S, Ji, Y, Wei, W, Xiao, S et al.. Consensus-based recommendations for the management of rapid cognitive decline due to Alzheimer's disease. Alzheimers Dement. 2017;13 (5):592-597. doi: 10.1016/j.jalz.2017.01.007. PubMed PMID:28238739 .
  67. Bergeron, D, Flynn, K, Verret, L, Poulin, S, Bouchard, RW, Bocti, C et al.. Multicenter Validation of an MMSE-MoCA Conversion Table. J Am Geriatr Soc. 2017;65 (5):1067-1072. doi: 10.1111/jgs.14779. PubMed PMID:28205215 .
  68. Zimmer, ER, Parent, MJ, Souza, DG, Leuzy, A, Lecrux, C, Kim, HI et al.. [18F]FDG PET signal is driven by astroglial glutamate transport. Nat. Neurosci. 2017;20 (3):393-395. doi: 10.1038/nn.4492. PubMed PMID:28135241 PubMed Central PMC5378483.
  69. Ismail, Z, Agüera-Ortiz, L, Brodaty, H, Cieslak, A, Cummings, J, Fischer, CE et al.. The Mild Behavioral Impairment Checklist (MBI-C): A Rating Scale for Neuropsychiatric Symptoms in Pre-Dementia Populations. J. Alzheimers Dis. 2017;56 (3):929-938. doi: 10.3233/JAD-160979. PubMed PMID:28059789 PubMed Central PMC5652315.
  70. Pascoal, TA, Mathotaarachchi, S, Shin, M, Benedet, AL, Mohades, S, Wang, S et al.. Synergistic interaction between amyloid and tau predicts the progression to dementia. Alzheimers Dement. 2017;13 (6):644-653. doi: 10.1016/j.jalz.2016.11.005. PubMed PMID:28024995 .
  71. Gauthier, S. Research update on Alzheimer's disease and introduction to the Expert Review of Neurotherapeutics special issue. Expert Rev Neurother. 2017;17 (1):1-2. doi: 10.1080/14737175.2017.1268054. PubMed PMID:27911115 .
  72. Ba, M, Kong, M, Li, X, Ng, KP, Rosa-Neto, P, Gauthier, S et al.. Is ApoE ɛ 4 a good biomarker for amyloid pathology in late onset Alzheimer's disease?. Transl Neurodegener. 2016;5 :20. doi: 10.1186/s40035-016-0067-z. PubMed PMID:27891223 PubMed Central PMC5112745.
  73. Gauthier, S, Feldman, HH, Schneider, LS, Wilcock, GK, Frisoni, GB, Hardlund, JH et al.. Efficacy and safety of tau-aggregation inhibitor therapy in patients with mild or moderate Alzheimer's disease: a randomised, controlled, double-blind, parallel-arm, phase 3 trial. Lancet. 2016;388 (10062):2873-2884. doi: 10.1016/S0140-6736(16)31275-2. PubMed PMID:27863809 PubMed Central PMC5164296.
  74. Mathotaarachchi, S, Wang, S, Shin, M, Pascoal, TA, Benedet, AL, Kang, MS et al.. VoxelStats: A MATLAB Package for Multi-Modal Voxel-Wise Brain Image Analysis. Front Neuroinform. 2016;10 :20. doi: 10.3389/fninf.2016.00020. PubMed PMID:27378902 PubMed Central PMC4908129.
  75. Schoemaker, D, Poirier, J, Escobar, S, Gauthier, S, Pruessner, J. Selective familiarity deficits in otherwise cognitively intact aging individuals with genetic risk for Alzheimer's disease. Alzheimers Dement (Amst). 2016;2 :132-9. doi: 10.1016/j.dadm.2015.11.007. PubMed PMID:27239534 PubMed Central PMC4879663.
  76. Gauthier, S, Rosa-Neto, P, Kass, JS. Ethical Considerations for the Use of Next-Generation Alzheimer Drugs in Symptomatic and At-Risk Patients. Continuum (Minneap Minn). 2016;22 (2 Dementia):615-8. doi: 10.1212/CON.0000000000000306. PubMed PMID:27042911 PubMed Central PMC5390936.
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